Product Overview

Silica Gel 400-700 mesh For Column Chromatography (CAS No. 112926-00-8) is a very fine amorphous silica stationary phase intended for specialised packed-bed chromatographic separations. Its extensive polar surface provides silanol-mediated adsorption, while the fine particle fraction can shorten diffusion distances and increase contact efficiency between analyte and stationary phase. Such particle fineness also increases hydraulic resistance, making flow control and packing quality particularly important to practical use.

The Column Chromatography product form is intended for fine-scale, high-contact preparative separation and method development where a 400-700 mesh silica fraction is deliberately required. It may be useful in specialised small columns or controlled-flow systems rather than routine coarse gravity columns.

Typical Applications

• Fine-scale preparative separation of closely retained compounds.
• Specialised normal-phase packed-column chromatography.
• Purification of small synthetic or natural-product samples.
• High-contact adsorptive cleanup of complex mixtures.
• Method development examining effects of very fine silica packing.
• Controlled-flow column separations where 400-700 mesh silica is specified.

Common Synonyms

• 400-700 mesh silica gel
• Column chromatography silica gel
• Amorphous silica gel
• Silica gel

Storage Conditions

Keep tightly closed and dry to preserve silica surface activity and prevent atmospheric moisture from altering retention behaviour. Protect the very fine material from dust, vapours, oils and cross-contamination, and use clean handling practices to maintain chromatographic background.