Product Overview

Silica Gel 60-120 mesh For Column Chromatography (CAS No. 112926-00-8) is a porous amorphous silica stationary-phase material supplied in the specified 60-120 mesh particle range. Surface silanol groups provide polar adsorption sites capable of interacting with analytes through hydrogen bonding, dipolar interactions and other surface forces. In normal-phase column chromatography, differences in these interactions permit separation according to molecular polarity and functional-group character.

The Column Chromatography product form is relatively coarse and is particularly suited to conventional gravity-fed and preparative columns where practical solvent flow and sample capacity are important. The 60-120 mesh range influences packing behaviour and hydraulic resistance without disclosing pore size, surface area or a specific adsorption-capacity value. Chromatographic resolution remains dependent on column dimensions, packing quality, solvent system and analyte chemistry.

Typical Applications

• Gravity column chromatography of organic reaction mixtures.
• Preparative separation of compounds with differing polarity.
• Fractionation of natural-product and synthetic-organic extracts.
• Cleanup of crude reaction mixtures before further purification.
• Adsorption-based separation using normal-phase solvent systems.
• Laboratory method development for coarse silica-gel columns.

Common Synonyms

• Column chromatography silica gel
• 60-120 mesh silica gel
• Chromatographic silica gel
• Amorphous silica gel
• Silica gel

Storage Conditions

Store tightly closed and dry because adsorbed atmospheric moisture changes silica surface activity and can alter chromatographic retention. Protect from organic vapours, dust and chemical contamination that could occupy active surface sites or introduce impurities into subsequent separations.